Summary

The Lab of Dr. Jeff Rosen research is based upon the philosophy that it necessary to first define the mechanisms regulating normal mammary gland development in order to understand the alterations in breast cancer. Specifically we have been interested in characterizing the role of Wnt and Fgf family members in normal mammary gland development and stem cell self-renewal, and the properties of tumor initiating cells including the mechanisms of resistance to standard of care therapies. We have a long history of developing syngeneic preclinical genetically engineered models of triple negative breast cancer that have been extensively characterized using different omics platforms and more recently with respect to their immune microenvironments. These models are being used to study critical questions of tumor heterogeneity, dormancy and recurrence with a focus on the treatment of metastatic triple negative breast cancer.

Job Duties

• Follows overall research objectives and protocols to design, set-up, conduct, and troubleshoot experiments.
• Evaluates protocols and data obtained from experiments and recommends changes to processes, procedures and techniques to improve the quality and validity of results based on project objectives.
• Prepares and conducts laboratory research experiments.
• Performs other job related duties as assigned as well as job duties that will require work with research mice.

Minimum Qualifications

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.