Senior Bioinformatics Scientist - Ghobrial Lab
Dana-Farber Cancer Institute
BOSTON, MA
Job posting number: #7340667 (Ref:dfJR-4434)
Posted: May 19, 2026
Job Description
The Ghobrial Lab has several large-scale, multi-institutional, research endeavors, such that the individual who fills this role will be critical to the data and quality management of the large multi-omic datasets produced and the data architecture and data transfer systems associated with each of these key research projects. The person will also be a key leadership contributor, together with the PI and Associate Director, to the strategic planning, operational implementation, and project management of the dry lab efforts.
The candidate will be expected to have a deep understanding of science, preferably with experience in computational biology, hematology, and/or cancer research and have a proven track record of managing large-scale multi-omic datasets. They will be adept at developing and maintaining close relationships with internal and external key stakeholders, as well as guiding and mentoring researchers through various project stages, from design to delivery and publication. A successful candidate will have strong emotional intelligence and cultural awareness as the internal team and scientific partners are international.
This individual will work together with PI and Associate Director to develop and implement data architecture and data management plans for assigned projects, will oversee the data produced on those projects from end to end (from data generation through analysis and publication and any associated data transfers) and will have wide decisional latitude for assigned projects and resources. The role will leverage assigned resources to support project progress, ensure synergy among various dry lab efforts, proactively identify and solve roadblocks, track and monitor project computational budgets, and ensure successful and timely completion. This role will be responsible for managing project risk and will be accountable in ensuring contractual and regulatory obligations on assigned projects are met.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
Primary Duties and Responsibilities
Bioinformaticsand Data Management
Design andmaintaindata architecture systems ensuring proper organization, documentation, and provenance tracking from generation through processing.
Manage Google Cloud Platform infrastructure including project lifecycle, access control, and cost monitoring.
Collaborate with wet-lab and computational biology teams toestablishdata management workflows and quality standards.
Develop andoptimizebioinformatics pipelines usingNextflowon Google Cloud Batch.
Providetechnical guidance on data sharing practices and ensure compliance with documentation requirements, and all institutional and regulatory guidelines.
Providescientific guidance on data analysis for sequencing data
Management of Scientific Project Deliverables, Collaborations,and Timelines:
Overseeassigned projects fromdata generationthrough deliveryand/or publication.
Work with leadership toprioritize efforts,setbudgets, and assign resources.
Ensure success of projectcomputationalmilestones associated with assigned projects,grantsand research efforts.
Maintainexpertisein the latest researchscholarshipandadvances in the field and provide scientific input onproposalsand project direction.
Integrate activities acrossmultipleteamsto maximize success of the overall projectoutput.
Ensure effective communicationand alignment ofeffortsacross all contributing computational collaboratorsbothinternal and external andtimelyreporting of progress to leadership and stakeholders.
Proactivelyidentifyandwork to resolveprojectroadblocks.
Manage the internal and external relationshipsand partnershipspertinent to theobjectivesof assigned projectcomputationalcollaborations.
Works closely with the leadership teamtopromotesynergyamong the various teams and efforts, and that the various initiatives together advance the overall scientific planning and researchobjectivesof the Lab.
Accountable for ensuringproject deadlines and contractual obligations are met for assigned projects.
Accountablefor the compliance of assigned projects.
ScientificLeadership:
Lead, mentor, and supervise the project team ofdry labresearchers.
Contribute criticallyto strategic planning and scientific direction of the research group’sportfolio of projects.
Drive innovation byidentifyingareas ofimprovementand development that align with those strategic goals.
Cultivate a deep understanding of the scientific principles,theoriesand methodologies within the hematology precursor space, as well as thecutting-edgetechnologiesand computational methodologiesleveragedby the field.
Guideresearchdesignandcomputational approachand provide critical feedback on progress.
Analyze and interpret scientific datato drawmeaningful conclusions and makerecommendations for future research direction.
Leverage existing multi-omics data to informstrategicdecision-makingas well as cohort design.
Ensuresynergyand efficiencyinresearch efforts across interdisciplinary teams including wet lab discovery, clinical research, and bioinformatics to ensuresynergyof the various project contributors.
Report onresearch progress and present results, both formally and informally.
Ensure that all research is conducted in compliance with regulatory and contractual obligationsas well as institutional and industrybest practices.
Key performance indicators for this role will include project completion rate, innovation impact of project output, dataintegrityand quality of project research output, as well as team development for assigned projects.
Knowledge, Skills and Abilities
Strongexpertisein cloud computing (Google Cloud Platform preferred) including infrastructure management and cost optimization.
Proficiencyin workflow management systems (Nextflow) and containerization technologies.
Experience with data architecture, version control, and reproducible research practices.
Demonstrated ability to collaborate across wet-lab and computational teams with excellent communication skills.
Demonstrated experience in complex, large-scaleprojector program management.
Demonstrated experience managing large databases.
Demonstrated experience managing budgets and resources on assigned projects.
Demonstrated experience in translational research.
Strong competencies in projectplanning andresource management with the ability to coordinate multiple activities and resources, whilemaintaininga focus on quality.
Impeccablewritten and oralcommunication and people skills.
Excellent documentation skills.
Demonstrated project team management skills.
Demonstratedexcellence inorganizational, problem-solving, and analytical skills.
Highly sophisticatedanalytical capabilities and impeccable attention to detail.
Ability to produce and present clear, concise, and professionally written communications and presentations.
Ability to condensehighly complexconcepts and information and present them in a clear and accessible manner.
Ability to clearly define and delegate tasks and deliverables.
Ability to manage multiple priorities with tight deadlines.
Versatility, flexibility, and a willingness to work with evolving priorities.
Demonstrated leadership skillsand leads by example.
Ability to work with greatindependence and successfully deliver on that work.
Thrivesin a fast-paced, mission-focusedenvironment.
Enjoysworking with peopleofdiverse backgrounds.
Entrepreneurial, self-starterand independent.
Excellent business software skills.
Minimum Job Qualifications
- Advanced degree preferred.
- 6+ years experience post education; One year management responsibility.
License/Certification/Registration Required: None
Supervisory Responsibilities:
- Manages the work efforts of at least one individual contributors and mentors.
- Completes performance appraisals.
Patient Contact: None
At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusiveenvironment where every patient, family, and staff member feels they belong. As relentless as we are in our mission to reduce the burden of cancer for all, we are committed to having faculty and staff who offer multifaceted experiences. Cancer knows no boundaries and when it comes to hiring the most dedicated and compassionateprofessionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.
Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.
EEO Poster
.Pay Transparency Statement
The hiring range is based on market pay structures, with individual salaries determined by factors such as business needs, market conditions, internal equity, and based on the candidate’s relevant experience, skills and qualifications.
For union positions, the pay range is determined by the Collective Bargaining Agreement (CBA).
$95,000.00 - $125,100.00Apply Now
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