Use Your Power for Purpose

At the heart of Pfizer's Digital transformation sits Infrastructure & Cloud, enabling modern cloud platforms and engineering capabilities that accelerate scientific discovery, empower researchers, and improve patient outcomes worldwide.

Pfizer is seeking a highly accomplished technology leader who combines enterprise-scale strategic thinking with deep technical expertise in cloud, infrastructure, networking, and platform engineering. This role will shape the future of Pfizer's cloud and infrastructure ecosystem, enabling AI/ML-powered research, advanced analytics, and next-generation digital capabilities that support breakthrough science and drug discovery.

The successful candidate will be equally comfortable discussing business strategy with executive leadership, guiding large-scale transformation initiatives, and engaging directly with architects and engineers on critical technical decisions. This is a leadership role for someone who has not only led transformation programs but has personally helped design, build, and scale modern cloud platforms and infrastructure capabilities.

At Pfizer, your work will directly contribute to the technologies that enable scientists to accelerate research, unlock insights from complex data, and develop innovative medicines for patients around the world.

Pfizer seeks individuals who are highly self-motivated, intellectually curious, collaborative, and committed to continuous learning and growth.

What You Will Achieve

The Senior Director, Cloud & Infrastructure Transformation serves as both a strategic technology executive and a technical thought leader for Pfizer's cloud and infrastructure landscape. This leader will define future-state infrastructure strategy while ensuring the successful execution of complex, enterprise-scale initiatives spanning cloud, networking, data center modernization, platform engineering, and AI infrastructure.

You will lead a team of senior leaders, architects, and engineering organizations while helping establish the technology vision, engineering standards, and operating models required to support Pfizer's digital future.

You will be expected to drive business outcomes through technology strategy while maintaining the technical depth and credibility necessary to guide architecture decisions, challenge assumptions, and ensure engineering excellence.

Key Responsibilities

• Define and execute Pfizer's multi-year cloud and infrastructure transformation strategy, aligning technology investments with business and scientific priorities.
• Lead enterprise-wide modernization initiatives spanning multi-cloud environments, AI/ML platforms, network transformation, infrastructure automation, and data center evolution.
• Serve as a senior technical authority, providing guidance on architecture, platform engineering, cloud operations, resiliency, security, and infrastructure modernization.
• Partner with architects and engineering leaders to evaluate and influence critical technology decisions, ensuring scalable, secure, and operationally resilient solutions.
• Drive adoption of cloud-native architectures, Infrastructure as Code, automation, observability, DevOps, and Site Reliability Engineering practices.
• Establish technology roadmaps and engineering standards that support innovation, operational excellence, and regulatory compliance.
• Build strong partnerships across Digital, Security, Research, and Business organizations to accelerate enterprise transformation initiatives.
• Lead and develop high-performing teams of Directors, Senior Managers, and technical leaders while cultivating a culture of innovation, accountability, and technical excellence. Mainly influencing to start, followed by a larger team over time.
• Influence senior executive stakeholders and drive alignment across a complex, global, matrixed organization.
• Evaluate emerging technologies and industry trends to identify opportunities that improve Pfizer's technology capabilities and business outcomes.
• Balance strategic priorities, execution risks, operational demands, and technical considerations to drive sustainable transformation at scale.
  

Leadership Expectations

Candidates should demonstrate a breadth of leadership experiences and capabilities, including:

• Influencing executive leaders, peers, and technical teams to achieve enterprise outcomes.
• Building organizational capability and developing future technology leaders.
• Creating an environment that promotes innovation, accountability, collaboration, and continuous improvement.
• Leading through ambiguity and driving execution in highly complex environments.
• Translating technology strategy into measurable business impact.
• Establishing credibility with both senior executives and highly technical engineering teams.
  

Here Is What You Need (Minimum Requirements)

• Bachelor's degree in Computer Science, Computer Engineering, Information Technology, or related discipline.
• 12+ years of progressive leadership experience in cloud, infrastructure, networking, platform engineering, or related technology functions.
• Demonstrated success leading large-scale cloud and infrastructure transformation programs at enterprise scale.
• Deep expertise in public cloud platforms (AWS, Azure, and/or GCP), with a proven history of designing, building, and operating production environments supporting critical business workloads.
• Strong technical foundation spanning cloud architecture, networking, platform engineering, infrastructure operations, automation, and security.
• Demonstrated ability to engage in architecture reviews, challenge technical design decisions, and influence engineering standards through technical expertise and credibility.
• Experience leading organizations responsible for cloud engineering, platform engineering, infrastructure automation, architecture, operations, and reliability.
• Proven success developing and leading senior technology leaders, including Senior Managers, Directors, and Architects.
• Extensive experience driving results through influence across business, security, engineering, and executive stakeholder groups.
• Expertise in cloud-native architectures, Infrastructure as Code (Terraform/OpenTofu), automation, DevOps, observability, resiliency engineering, and modern operating models.
• Strong understanding of cybersecurity, compliance, and risk management practices within large enterprise environments.
• Exceptional communication skills with the ability to translate complex technical concepts into business-focused recommendations.
• Proven ability to simultaneously lead strategic planning and execution across multiple complex initiatives.
  

Preferred Qualifications

• Experience building or enabling AI/ML infrastructure, advanced analytics platforms, or high-performance computing environments.
• Experience supporting research, scientific computing, or large-scale data science workloads.
• Pharmaceutical, biotechnology, healthcare, or other highly regulated industry experience.
• Advanced degree in Computer Science, Engineering, Technology Management, or Business Administration.
• Industry certifications in cloud architecture, engineering, security, or infrastructure platforms.
• Experience leading global organizations across multiple regions, cultures, and time zones.
• Experience with enterprise-scale migrations, data center exits, platform modernization initiatives, or mergers and acquisitions.
• Demonstrated success driving technology transformation through both strategic vision and deep technical leadership.
  

Ideal Candidate Profile

The ideal candidate is a technology strategist and engineer at heart. They have built credibility through hands-on technical leadership, can engage deeply in architectural discussions, and have successfully led large-scale transformation efforts that delivered measurable business value. They are equally effective influencing executive stakeholders, mentoring technical leaders, and driving execution across complex enterprise environments.

Most importantly, this leader brings both the strategic mindset to shape Pfizer's future and the technical depth to help build it.

Other Job Details

• Last day to apply: 9/7/2026

• Work location assignment: Hybrid - onsite at NY Headquarters an average of 2.5 days per week or as the business requires

• 10-20% Travel


The annual base salary for this position ranges from $214,900.00 to $358,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 22.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.





Relocation assistance may be available based on business needs and/or eligibility.




Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN, O-1, H-1B, etc.) is not available for this role now or in the future.






To learn more about acceptable and prohibited uses of AI during the recruitment process, please review our candidate AI-use guidelines available onPfizer Careers.


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